RT Journal A1 Grady D, Berkowitz SA T1 WHy is a good clinical prediction rule so hard to find? JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2011 FD October 24 VO 171 IS 19 SP 1701 OP 1702 DO 10.1001/archinternmed.2011.482 UL http://dx.doi.org/10.1001/archinternmed.2011.482 AB Clinical prediction rules (CPRs) (also called clinical decision rules, prediction models, and risk scores) are tools designed to assist clinical decision making. Clinical prediction rules generally provide an estimate of the risk of disease, disease outcome, or the benefit of a diagnostic or therapeutic action.1- 2 For example, the well-known Framingham Risk Score3 uses age, sex, total cholesterol level, high-density lipoprotein cholesterol level, smoking status, blood pressure, and use of hypertension medication to estimate the risk of myocardial infarction or coronary death during the next 10 years. Because CPRs are designed to guide clinical care, it is important that they be accurate and reliable.