RT Journal
A1 Altman D
T1 Risk of renal cell carcinoma after hysterectomy: Is it all obesity?—reply
JF Archives of Internal Medicine
JO Archives of Internal Medicine
YR 2011
FD July 11
VO 171
IS 13
SP 1215
OP 1216
DO 10.1001/archinternmed.2011.304
UL http://dx.doi.org/10.1001/archinternmed.2011.304
AB 
In lieu of other explanations for the observed association between hysterectomy and renal cancer, we welcome the argument put forth by Drs Goldstein and Mascitelli. Indeed, the suggested influences of VEGF and iron accumulation on the association are 2 biologically plausible explanations worthy of further exploration because they are amenable to intervention in women with an increased risk. Although our study provides robust epidemiological evidence linking hysterectomy with an increased risk for renal cancer later in life, we recognize the need for further clinical and experimental research to substantiate our findings and to determine why (and which) younger women in particular are at increased risk for renal cancer after hysterectomy on benign indications.