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Research Letters |

Sustained Cognitive and Economic Benefits of Resistance Training Among Community- Dwelling Senior Women: A 1-Year Follow-up Study of the Brain Power Study FREE

Jennifer C. Davis, MSc, PhD; Carlo A. Marra, PharmD, PhD; B. Lynn Beattie, MD; M. Clare Robertson, PhD; Mehdi Najafzadeh, MSc; Peter Graf, PhD; Lindsay S. Nagamatsu, MA; Teresa Liu-Ambrose, PT, PhD
[+] Author Affiliations

Author Affiliations: The Centre for Hip Health and Mobility (Drs Davis and Liu-Ambrose) and The Brain Research Centre (Drs Beattie, Graf, and Liu-Ambrose and Ms Nagamatsu), Vancouver Coastal Health Research Institute, Collaboration for Outcomes Research and Evaluation (CORE), Faculty of Pharmaceutical Sciences (Drs Davis and Marra and Mr Najafzadeh), Department of Physical Therapy (Dr Liu-Ambrose), Department of Psychology (Dr Graf), and Division of Geriatric Medicine, Faculty of Medicine (Dr Beattie), University of British Columbia, Vancouver, British Columbia, Canada; and Otago School of Medicine, University of Otago, Dunedin, New Zealand (Dr Robertson).


Arch Intern Med. 2010;170(22):2036-2038. doi:10.1001/archinternmed.2010.462.
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Cognitive decline is a major public health care issue, and a well-recognized clinical manifestation of cognitive decline is falls. Seniors with cognitive impairment fall at twice the rate of peers without cognitive impairment.1,2

Exercise training may be an effective strategy against cognitive decline,36 and it is recommended for prevention of falls. We recently reported that 12 months of once-weekly (1 × RT) or twice-weekly (2 × RT) resistance training improved selective attention and conflict resolution compared with a balance and tone program (BAT; control) among 155 community-dwelling senior women (ie, Brain Power resistance training study).4We also found that both resistance training programs provided better value for falls prevented compared with the BAT program.7To our knowledge, no study has examined whether both cognitive and economic benefits of exercise persist after formal cessation. Hence, we examined whether improved selective attention and conflict resolution as well as economic benefits were sustained 12 months after formal cessation of the Brain Power resistance training study.

We conducted a 12-month follow-up study from May 2008 to April 2009. Of the original 155 participants, 123 consented to the follow-up study. Ethics approval was obtained from the Vancouver Coastal Health Research Institute and the University of British Columbia's Clinical Research Ethics Board.

Our primary outcome measure was the specific executive cognitive function of selective attention and conflict resolution, as measured by the Stroop Test.8 Secondary measures included set shifting, working memory, and current physical activity level.

Between-group differences in executive cognitive functions were compared by multiple linear regression analyses as in our original trial.4 For current physical activity level, baseline score and experimental group were used as covariates. Two planned simple contrasts were performed to assess differences between (1) the 1 × RT group and the BAT group and (2) the 2 × RT group and the BAT group. The overall α level was set at P < .05.

For the economic evaluation, we calculated the incremental cost per fall prevented for both 1 × RT and 2 × RT groups compared with the BAT group from a Canadian Health Care System perspective using a 21-month time horizon (2009 prices). All hospital admission–related costs were based on a fully allocated cost model of a tertiary care hospital or the British Columbia Medical Services Plan 2009 price list.

Of the 123 who consented, 109 completed the assessment at the end of the 12-month follow-up (37 from the 1 × RT group, 41 from the 2 × RT group, and 31 from the BAT group). The mean (SD) age of the cohort was 71.6 (3.0) years.

There was a significant between-group difference in selective attention and conflict resolution at the end of the 12-month follow-up study (P = .04). Specifically, the 1 × RT group sustained improved Stroop test performance compared with the BAT group (P = .04) (Table). There were no significant between-group differences in set shifting, working memory, and current physical activity level.

Table Graphic Jump LocationTable. Outcome Measures and Results of Base Case Analysis for Economic Evaluation

The unadjusted incidence rate ratio over the 2-year period for the 1 × RT group indicated a 30% (incidence rate ratio, 0.70; 95% confidence interval, 0.37-1.33) nonsignificant reduction in falls and an 8% (incidence rate ratio, 1.08; 95% confidence interval, 0.79-1.47) nonsignificant increase in the 2 × RT group.

On the basis of the point estimates from our base case analysis, we found that the 1 × RT group incurred fewer health care resource utilization costs and had fewer falls than the BAT group; thus, 1 × RT was less costly and more effective than BAT. Although the 2 × RT group also incurred fewer care utilization costs than BAT, the 2 × RT group sustained more falls. Thus, 2 × RT was less effective than BAT.

We provide novel data suggesting that both the cognitive and economic benefits of once-weekly resistance training can be sustained 12 months after its formal cessation. Specifically, 12 months after trial completion, former participants of the 1 × RT group demonstrated a 15% improvement in their performance on the Stroop test compared with those in the BAT group. This novel finding strengthens the emerging belief that targeted exercise training may combat age-related decreases in cognitive function. Furthermore, there was a significant reduction in health care resource utilization costs of falls 12 months after trial completion for the 1 × RT and 2 × RT groups compared with the BAT (control) group. Thus, both cognitive and economic benefits of participating in a 12-month resistance training intervention were sustained for the 1 × RT group, whereas these benefits were not sustained for the 2 × RT group. The 1 × RT group demonstrated a 5% increase (P > .05) in current physical activity level from baseline compared with a 6.6% reduction (P > .05) in the 2 × RT group. Hence, maintaining physical activity level may be essential in sustaining the benefits of resistance training. Such findings should remain guarded as future studies investigate factors that explain this observed variation in exercise-induced cognitive benefits in terms of costs and consequences.

Correspondence: Dr Liu-Ambrose, Department of Physiotherapy, University of British Columbia, 311-2647 Willow St, Vancouver, BC V5Z 3P1, Canada (tlambrose@exchange.ubc.ca).

Author Contributions: All authors had full access to all of the data (including statistical reports and tables) in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Marra, Beattie, Graf, and Liu-Ambrose. Acquisition of data: Nagamatsu and Liu-Ambrose. Analysis and interpretation of data: Marra, Beattie, Robertson, Najafzadeh, Nagamatsu, and Liu-Ambrose. Drafting of the manuscript: Liu-Ambrose. Critical revision of the manuscript for important intellectual content: Marra, Beattie, Robertson, Najafzadeh, Graf, Nagamatsu, and Liu-Ambrose. Statistical analysis: Marra, Najafzadeh, and Liu-Ambrose. Obtained funding: Beattie, Graf, and Liu-Ambrose. Administrative, technical, and material support: Nagamatsu and Liu-Ambrose. Study supervision: Marra, Robertson, and Liu-Ambrose.

Financial Disclosure: None reported.

Funding/Support: The Vancouver Foundation (BCMSF, operating grant to Dr Liu-Ambrose) and the MSFHR (establishment grant to Dr Liu-Ambrose) provided funding for this study. The Canada Foundation for Innovation funded essential infrastructure used in this study (new opportunities fund to Dr Liu-Ambrose).

Trial Registration: clinicaltrials.gov Identifier: NCT00426881

Additional Information: Drs Marra and Liu-Ambrose are Michael Smith Foundation for Health Research Scholars. Dr Marra is a Canada Research Chair in Pharmaceutical Outcomes. Dr Davis is a Canadian Institutes for Health Research Canada Graduate Scholarship PhD trainee.

Additional Contributions: We thank the Vancouver South Slope YMCA management and members who enthusiastically supported the study by allowing access to participants for the training intervention and the instructors for their commitment to the participants' health and safety.

Tinetti  MESpeechley  MGinter  SF Risk factors for falls among elderly persons living in the community. N Engl J Med 1988;319 (26) 1701- 1707
PubMed
van Dijk  PTMeulenberg  OGvan de Sande  HJHabbema  JD Falls in dementia patients. Gerontologist 1993;33 (2) 200- 204
PubMed
Liu-Ambrose  TDonaldson  MGAhamed  Y  et al.  Otago home-based strength and balance retraining improves executive functioning in older fallers: a randomized controlled trial. J Am Geriatr Soc 2008;56 (10) 1821- 1830
PubMed
Liu-Ambrose  TNagamatsu  LSGraf  PBeattie  BLAshe  MCHandy  TC Resistance training and executive functions: a 12-month randomized controlled trial. Arch Intern Med 2010;170 (2) 170- 178
PubMed
Colcombe  SJKramer  AFErickson  KI  et al.  Cardiovascular fitness, cortical plasticity, and aging. Proc Natl Acad Sci U S A 2004;101 (9) 3316- 3321
PubMed
Cassilhas  RCViana  VAGrassmann  V  et al.  The impact of resistance exercise on the cognitive function of the elderly. Med Sci Sports Exerc 2007;39 (8) 1401- 1407
PubMed
Davis  JCMarra  CRobertson  MC  et al.  Economic evaluation of dose-response resistance training in older women: a cost effectiveness and cost utility analysis [published online August 4, 2010]. Osteoporos Int
PubMed10.1007/s00198-010-1356-5
Graf  PUttl  BTuokko  H Color- and picture-word Stroop tests: performance changes in old age. J Clin Exp Neuropsychol 1995;17 (3) 390- 415
PubMed

Figures

Tables

Table Graphic Jump LocationTable. Outcome Measures and Results of Base Case Analysis for Economic Evaluation

References

Tinetti  MESpeechley  MGinter  SF Risk factors for falls among elderly persons living in the community. N Engl J Med 1988;319 (26) 1701- 1707
PubMed
van Dijk  PTMeulenberg  OGvan de Sande  HJHabbema  JD Falls in dementia patients. Gerontologist 1993;33 (2) 200- 204
PubMed
Liu-Ambrose  TDonaldson  MGAhamed  Y  et al.  Otago home-based strength and balance retraining improves executive functioning in older fallers: a randomized controlled trial. J Am Geriatr Soc 2008;56 (10) 1821- 1830
PubMed
Liu-Ambrose  TNagamatsu  LSGraf  PBeattie  BLAshe  MCHandy  TC Resistance training and executive functions: a 12-month randomized controlled trial. Arch Intern Med 2010;170 (2) 170- 178
PubMed
Colcombe  SJKramer  AFErickson  KI  et al.  Cardiovascular fitness, cortical plasticity, and aging. Proc Natl Acad Sci U S A 2004;101 (9) 3316- 3321
PubMed
Cassilhas  RCViana  VAGrassmann  V  et al.  The impact of resistance exercise on the cognitive function of the elderly. Med Sci Sports Exerc 2007;39 (8) 1401- 1407
PubMed
Davis  JCMarra  CRobertson  MC  et al.  Economic evaluation of dose-response resistance training in older women: a cost effectiveness and cost utility analysis [published online August 4, 2010]. Osteoporos Int
PubMed10.1007/s00198-010-1356-5
Graf  PUttl  BTuokko  H Color- and picture-word Stroop tests: performance changes in old age. J Clin Exp Neuropsychol 1995;17 (3) 390- 415
PubMed

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