In this prospective cohort study, Terry et al examined cardiac risk factors, including the Framingham Risk Score (FRS) at examination cycle 1 and longitudinally in 1697 Framingham Heart Study (FHS) offspring members by the survival status of their parents, who were members of the original cohort of the FHS. The offspring participants were grouped according to whether neither, one, or both parents survived to age 85 years. For all factors studied, except body mass index, the authors observed statistically significant linear trends for lower offspring risk factor levels with increasing parental survival category. Longitudinally, offspring of parents who lived longer had lower risk of blood pressure and FRS progression. These findings suggest that individuals with long-lived parents have advantageous cardiovascular risk profiles in middle age compared with those whose parents died younger.