Recent otolaryngologic reports document significant fatigue and bodily pain in patients with chronic rhinosinusitis, but studies of general medical patients are lacking. To determine the prevalence and significance of rhinosinusitis symptoms in those with unexplained chronic fatigue (UCF) and/or bodily pain, 297 consecutive general medical outpatients were studied: 65 patients noted UCF; 33, unexplained bodily pain; and 26, both. When patients with UCF were compared with the 232 remaining patients without UCF, the following rhinosinusitis symptoms were significantly more common in patients with UCF: facial pressure, heavy headedness, nasal obstruction, frontal headache, postnasal drip, sore throat, and tender anterior cervical lymph nodes. A similar predominance of rhinosinusitis symptoms was noted in patients with bodily pain and in 15 UCF patients with chronic fatigue syndrome. No increased prevalence of pollen allergy was noted in patients with UCF, unexplained bodily pain, or chronic fatigue syndrome. When those with UCF were compared with 38 patients with explained fatigue, rhinosinusitis symptoms were more common in UCF. This study notes an increased prevalence of rhinosinusitis symptoms but not pollen allergy in general medical outpatients with UCF and/or bodily pain.