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Comments, Opinions, and Brief Case Reports |

Association Between Folic Acid Food Fortification and Hypertension or Preeclampsia in Pregnancy

Joel G. Ray, MD, FRCPC, MSc; Muhammad M. Mamdani, PharmD, MA, MPH
Arch Intern Med. 2002;162(15):1776-1777. doi:.
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From April 1990 to March 2000, the overall rate of preeclampsia did not significantly change before (3.8%) and after (3.7%) the introduction of a mandatory Canadian folic acid food fortification program in January 1998.

Ray  JGLaskin  CA Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review. Placenta. 1999;20519- 529
Link to Article[[XSLOpenURL/10.1053/plac.1999.0417]]
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Link to Article[[XSLOpenURL/10.1016/0002-9378(90)90653-O]]
Not Available, Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 2000;183S1- S22
Link to Article[[XSLOpenURL/10.1016/S0002-9378(00)99785-0]]
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Link to Article[[XSLOpenURL/10.1016/S0140-6736(00)03599-6]]
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Link to Article[[XSLOpenURL/10.1016/S0378-3782(01)00181-5]]
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Link to Article[[XSLOpenURL/10.1097/00001648-200203000-00026]]
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Monthly rate of preeclampsia-eclampsia (lower curve) or any hypertension in pregnancy (upper curve) before and after folic acid food fortification (dashed line). ARIMA indicates autoregressive integrated moving average.

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