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Association Between Folic Acid Food Fortification and Hypertension or Preeclampsia in Pregnancy

Joel G. Ray, MD, FRCPC, MSc; Muhammad M. Mamdani, PharmD, MA, MPH
Arch Intern Med. 2002;162(15):1776-1777. doi:.
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From April 1990 to March 2000, the overall rate of preeclampsia did not significantly change before (3.8%) and after (3.7%) the introduction of a mandatory Canadian folic acid food fortification program in January 1998.

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Dawson  LEPham  BHunter  AG Low rate of adequate folic acid supplementation in well-educated women of high socioeconomic status attending a genetics clinic. CMAJ. 2001;1641149- 1150
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Monthly rate of preeclampsia-eclampsia (lower curve) or any hypertension in pregnancy (upper curve) before and after folic acid food fortification (dashed line). ARIMA indicates autoregressive integrated moving average.

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