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Comments, Opinions, and Brief Case Reports |

Association Between Folic Acid Food Fortification and Hypertension or Preeclampsia in Pregnancy

Joel G. Ray, MD, FRCPC, MSc; Muhammad M. Mamdani, PharmD, MA, MPH
Arch Intern Med. 2002;162(15):1776-1777. doi:.
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From April 1990 to March 2000, the overall rate of preeclampsia did not significantly change before (3.8%) and after (3.7%) the introduction of a mandatory Canadian folic acid food fortification program in January 1998.

Ray  JGLaskin  CA Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review. Placenta. 1999;20519- 529
Link to Article[[XSLOpenURL/10.1053/plac.1999.0417]]
National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy, Report on high blood pressure in pregnancy. Am J Obstet Gynecol. 1990;1631691- 1712
Link to Article[[XSLOpenURL/10.1016/0002-9378(90)90653-O]]
Not Available, Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 2000;183S1- S22
Link to Article[[XSLOpenURL/10.1016/S0002-9378(00)99785-0]]
Dekker  GSibai  B Primary, secondary, and tertiary prevention of pre-eclampsia. Lancet. 2001;357209- 215
Link to Article[[XSLOpenURL/10.1016/S0140-6736(00)03599-6]]
Dawson  LEPham  BHunter  AG Low rate of adequate folic acid supplementation in well-educated women of high socioeconomic status attending a genetics clinic. CMAJ. 2001;1641149- 1150
McMahon  MJAnanth  CVListon  RM Gestational diabetes mellitus: risk factors, obstetric complications and infant outcomes. J Reprod Med. 1998;43372- 378
Ray  JGBurrows  RFBurrows  EAVermeulen  MJ MOS HIP: McMaster Outcome Study of Hypertension in Pregnancy. Early Hum Dev. 2001;64129- 143
Link to Article[[XSLOpenURL/10.1016/S0378-3782(01)00181-5]]
Homocysteine Lowering Trialists' Collaboration, Lowering blood homocysteine with folic acid-based supplements: meta-analysis of randomised trials. Indian Heart J. 2000;52S59- S64
Ray  JGVermeulen  MJBoss  SCCole  DE Increased red cell folate concentrations in women of reproductive age after Canadian folic acid food fortification. Epidemiology. 2002;13238- 240
Link to Article[[XSLOpenURL/10.1097/00001648-200203000-00026]]
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Monthly rate of preeclampsia-eclampsia (lower curve) or any hypertension in pregnancy (upper curve) before and after folic acid food fortification (dashed line). ARIMA indicates autoregressive integrated moving average.

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