Editor's Correspondence |

Reduction of Buffalo Hump by Switching to Amprenavir in an HIV-Infected Patient

Homayoun Khanlou, MD; Mary Adair, PA-C; Charles Farthing, MD
Arch Intern Med. 2000;160(22):3495-3496. doi:.
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Certain human immunodeficiency virus (HIV)–infected patients, within 6 to 18 months of the initiation of antiretroviral therapy, develop fat redistribution abnormalities consisting of body peripheral fat wasting with central fat deposition.1,2 Treatment of these morphological abnormalities remains a difficult challenge for case management. However, there are few clinical data to support the ability of amprenavir (Agenerase) to cause less lipodystrophy. We describe a patient whose buffalo hump was reduced by changing his regimen from indinavir sulfate (Crixivan) to amprenavir.

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hiv ; amprenavir

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Figure 1.

Buffalo hump during indinavir therapy.

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Figure 2.

Reduction of buffalo hump after the patient's regimen was changed to amprenavir.

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