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Editor's Correspondence |

Invasive Aspergillosis in a Patient With Ticlopidine-Induced Agranulocytosis

Sofia Rimbrot; Elena Kundzinsh; Yishai Levy
Arch Intern Med. 2000;160(22):3495-3496. doi:.
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We describe a patient with multiple lung and skin lesions, cultures of which yielded Aspergillus species during a prolonged course of pancytopenia and agranulocytosis. Although the correlation between neutropenia and an increased risk of aspergillosis is well known, to our knowledge ours is the first case in which ticlopidine hydrochloride triggered this chain of events.

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Gerson  STalbot  GHurwitz  S  et al.  Prolonged granulocytopenia: the major risk factor for invasive aspergillosis in patients with acute leukemia. Ann Intern Med. 1984;100345- 351
Kaiser  LHuguenin  TLew  DChapuis  BPittet  D Invasive aspergillosis. Medicine (Baltimore). 1998;7188- 194
Sharis  PCannon  CLoscalzo  J The antiplatelet effects of ticlopidine and clopidogrel. Ann Intern Med. 1998;129394- 405

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