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Editor's Correspondence |

Hypertensive Crisis Following Meperidine Administration and Chemoembolization of a Carcinoid Tumor

Lori M. Balestrero, MD; Cathleen R. Beaver, MD; James R. Rigas, MD
Arch Intern Med. 2000;160(15):2393. doi:.
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A 70-year-old woman with a metastatic carcinoid tumor in the liver was admitted to the hospital for management of systolic hypertension following chemoembolization. The patient underwent chemoembolization through catheterization of the left hepatic artery with 60 mg of doxorubicin hydrochloride in 10 mL of diatrizoate meglumine. One hour and 30 minutes prior to initiation of chemoembolization, the patient was given octreotide acetate, dexamethasone sodium phosphate, and 10 mg per hour of meperidine hydrochloride by continuous intravenous infusion.1 The patient had previously experienced severe nausea from intravenous morphine; therefore meperidine was selected for narcotic anaglesia.

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Serotonin (5-hydroxytryptamine [5-HT]) synapse. Meperidine hydrochloride blocks the presynaptic 5-HT reuptake pathway. 5-HIAA indicates 5-hydroxyindoleacetic acid.

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