Pyoderma gangrenosum is a disorder that can be idiopathic or associated with several systemic conditions, the most frequent being inflammatory bowel disease (in particular ulcerative colitis), rheumatoid arthritis, paraproteinemia (mainly IgA), and hematologic neoplasias.1- 3 Pathergy is also commonly seen in patients with PG and usually presents because of a previous mild lesion, such as a needle puncture.2 Pathergic reaction, which was observed as a skin lesion (pustule or papule) by Blobner4 in 1937, appears some hours after a puncture on the skin and is nonspecific. It has also been described in other conditions such as Behçet disease, rheumatoid arthritis, sarcoidosis, idiopathic erythema nodosum, and genital herpes.
Large ulcerated lesion in the abdominal region.
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