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May 1918, Vol XXI, No. 5 >
ARTICLE | May 1918

A FURTHER STUDY OF ETHYLHYDROCUPREIN (OPTOCHIN) IN THE TREATMENT OF ACUTE LOBAR PNEUMONIA

HENRY F. MOORE, M.D., B.Ch.; ALAN M. CHESNEY, M.D.
Arch Intern Med (Chic). 1918;XXI(5):659-681. doi:10.1001/archinte.1918.00090100096006.
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In a previous communication1 we reported on a series of thirty-two cases of lobar pneumonia due to pneumococci and treated with ethylhydrocuprein (optochin) hydrochlorid. By means of bactericidal tests of the patient's serum in vitro the absorption and elimination of the drug in these cases was studied. It was concluded that the hydrochlorid of the drug is rapidly absorbed from the gastro-intestinal tract into the circulating blood; that when an amount of the hydrochlorid represented by 0.024 to 0.026 gm. per kilogram of body weight of the patient is administered by mouth per twenty-four hours, the blood serum of the patient acquires the property of destroying pneumococci in the test tube; that the best way to insure the rapid production and maintenance of this bactericidal action in the blood is to divide the total amount of the drug in such a way that the first dose is relatively large and

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