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Arch Intern Med (Chic). 1918;XXI(2):292-308. doi:10.1001/archinte.1918.00090080119011.
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REVIEW OF THE LITERATURE  The following experimental work was begun in the summer of 1915, at the suggestion of Dr. A. J. Carlson, as a further contribution toward the explanation of the cause of death in acute ileus, or high intestinal obstruction. The theories propounded to explain the fatal issue in high intestinal obstruction in man, studied comparatively in animals, are almost as diverse as the number of workers in the field. Chief among the theories that have been submitted since systematic experimentation was begun in this line may be enumerated the following:

  1. Splanchnic paresis, or disorder of the nervous mechanism controlling the cardiac and vasomotor systems, due to irritation of the nerves in the intestinal wall.

  2. Bacterial infection, or outward passage of bacteria through the intestinal wall; invading the peritoneum and producing a peritonitis, or invading the blood and lymphatics and producing a septicemia.

  3. Autointoxication, or the absorption of various poisons


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