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CHEMICAL CHANGES IN THE BLOOD AND URINE IN PROGRESSIVE MUSCULAR DYSTROPHY, PROGRESSIVE MUSCULAR ATROPHY AND MYASTHENIA GRAVIS

F. H. McCRUDDEN, M.D.; C. S. SARGENT, S.B.
Arch Intern Med (Chic). 1918;XXI(2):252-255. doi:10.1001/archinte.1918.00090080079006.
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In May, 1916, we1 reported the following findings in a case of progressive muscular dystrophy: (1) low blood sugar; (2) low cholesterin content of the blood; (3) creatinuria; (4) a rise in the sugar content of the blood accompanied by a corresponding increase, in muscular strength following treatment.

We now submit further data2 regarding the first patient, and figures for the glucose and cholesterin content of the blood and the creatin content of the urine in other cases of progressive muscular dystrophy, in progressive muscular atrophy, in myasthenia gravis, and — as controls — in conditions not accompanied by myasthenia of any form.3

BLOOD SUGAR  The blood sugar in these cases (nephritis, progressive muscular dystrophy and myasthenia gravis excepted) falls between 0.09 and 0.13 per cent.6 Since but few of these patients were in good health, the figures are not offered as normal standards; but other investigators have found approximately

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