On account of the peculiar course of pernicious anemia, characterized as it is by marked remissions, there has always been great difficulty in judging fairly the effect of any method treatment. Brilliant results have been reported in certain cases from almost every therapeutic measure employed, yet it is impossible to say in many of these cases that a spontaneous remission was not beginning at the time of treatment, since the blood picture often fails to give this information. It is therefore desirable that a more reliable method be employed for determining the different stages in the course of the disease.
Since this form of anemia is accompanied by a greatly increased blood destruction, it seems not unreasonable to assume that the quantity of blood being destroyed may be regarded as an indication of the severity of the disease process. This can be determined by estimating the