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June 1915, Vol XV, No. 6 >
ARTICLE | June 1915

STUDY XXIV: THE EFFECT OF THEOBROMIN SODIUM SALICYLATE IN ACUTE CHROMATE NEPHRITIS

JAMES P. O'HARE, M.D.
Arch Intern Med (Chic). 1915;XV(6):1053-1058. doi:10.1001/archinte.1915.00070250114008.
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The effect of diuretics in acute nephritis has been the subject of much theorization and of some experimental work, especially during the past few years. The meager literature on the experimental work has been so recently reviewed by Fitz1 in his article on the "Immediate Effect of Repeated Doses of Theobromin Sodium Salicylate and Theocin in Acute Experimental Nephritis" that it does not seem worth while repeating it here. In 1913 with Dr. Christian2 I reported the results of our experiments on the effect of theobromin sodium salicylate on the duration of life of rabbits with acute uranium nephritis, and Walker and Dawson3 reported in the same way the effects of theocin, caffein, potassium acetate, spartein sulphate and water. More recently Dr. Christian4 has reported the effect of theobromin sodium salicylate on renal function as measured by the excretion of phenolsulphonephthalein in acute uranium

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