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STUDIES IN RENAL FUNCTION WITH SPECIAL REFERENCE TO NON-PROTEIN NITROGEN AND SUGAR CONCENTRATION IN THE BLOOD, PHENOLSULPHONEPHTHALEIN ELIMINATION AND BLOOD PRESSURE

ARTHUR H. HOPKINS, M.D.; LEON JONAS, M.D.
Arch Intern Med (Chic). 1915;XV(6):964-973. doi:10.1001/archinte.1915.00070250021003.
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Until the theories of nephritis are reduced to one and until that one has been conclusively proved to be correct, continued investigations, both clinical and experimental, seem to be demanded.

These studies in nephritis deal on the one hand, with the accumulation or retention in the blood of the end-products of protein metabolism and glucose concentration in the blood, and on the other hand, with the functional capacity of the kidneys in so far as the latter may be determined by the elimination of phenolsulphonephthalein. In short, the purpose of this paper is to study :

  1. The relation of protein feeding to nitrogen retention in the blood.

  2. The relation of nitrogen retention to renal function.

  3. The relation of blood-sugar, blood-pressure, phenolsulphonephthalein elimination and nitrogen retention.

So far as we can ascertain, there have been no studies covering all of these phases simultaneously and the possible

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