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ARTICLE |

VARIATIONS IN THE TOXICITY OF CHLOROFORM FOR ANESTHESIA

WORTH HALE, M.D.
Arch Intern Med (Chic). 1915;XV(6):945-954. doi:10.1001/archinte.1915.00070250002001.
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In considering the toxicity of chloroform it is necessary to recall that a number of chemical processes are involved in its manufacture and that, in the various processes, a considerable number of chemical substances interact to give chloroform as one of the main products. Other products are formed, however, or remain from the mother substances which are used in the manufacturing process. The chloroform itself, of course, does not differ whether it be derived from acetone,1 alcohol, methane, carbon tetrachlorid1 or chloral, but there exist on the market many grades of chloroform, more or less contaminated with by-products of manufacture, in addition to the very best anesthetic grades freed from these products by purification, all of which are known under the general term "chloroform." Even chloroform of the anesthetic grade, however, is not pure CHCl3 but contains in addition a small amount of

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