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Arch Intern Med (Chic). 1915;XV(5_1):659-713. doi:10.1001/archinte.1915.00070230016003.
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Since the original papers of Bamberger12,13 (1889 and 1891) and Marie113 (1890) numerous reports have been published which have more and more definitely established this morbid condition as a distinct clinical entity among the general group of allied diseases, including leontiasis ossae, osteitis deformans, acromegaly, rickets, syphilis of the bones and others. Walters210 (1896), Massalongo117 (1897), Janeway88 (1903), Thompson192 (1904), Wynn218 (1904), Ebstein48 (1906) and Alexander3 (1906) have each collected the typical cases from the literature and given a critical review, together with a general discussion of the diseases. In spite of these and many other excellent reports, much regarding the cause, course and real nature of the pathologic changes remains obscure.

The object of the present report is to record the results of the study of five typical cases for a period of years with reference to such con


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