Scope of the problem and general considerations.
Character of the cases and their general treatment.
Technic employed ; interpretation of results.
Dosage of optochin :
Oral administration entirely. The various methods of dosage used ; comparison. Relationship between body weight of patient and appearance of bactericidal action in the serum.
Combined intramuscular and oral administration.
Occurrence of "spreads."
Duration of the disease.
The valuable studies of Morgenroth and his co-workers1 on the chemotherapy of the quinin alkaloids have shown that ethylhydrocuprein (optochin) has a specific bactericidal effect on the pneumococcus in vitro, and that this compound exerts a protective and curative action in animals experimentally infected with virulent strains of that micro-organism. The specific germicidal action of ethylhydrocuprein on the pneumococcus