We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......


Arch Intern Med (Chic). 1917;XIX(3):344-353. doi:10.1001/archinte.1917.00080220011002.
Text Size: A A A
Published online

The lemon yellow color of the skin in pernicious anemia has always been closely associated with the idea of jaundice and is often referred to as an icteroid hue. But the almost invariable absence of bile from the urine has stood in the way of our calling pernicious anemia patients definitely jaundiced. The frequent appearance of urobilin in the urine has suggested an explanation for the color of the skin, and we frequently see the term ``urobilin icterus'' in this connection.

Hemolysis, which is the most definite pathologic entity of pernicious anemia, is also fundamentally associated with the symptom jaundice and we are therefore enticed by the term "hemolytic jaundice" in pernicious anemia.

Just what relation exists between the appearance of bile pigments in the blood and the yellow pigmentation of the skin in pernicious anemia has been the object of this investigation.

The presence of bile in


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.