Arch Intern Med (Chic). 1917;XIX(1):156-162. doi:10.1001/archinte.1917.00080200163009.
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In this, our second year's work, we have entertained with reference particularly to pernicious anemia a twofold objective, namely, the determination of pigment values after splenectomy in cases estimated quantitatively prior to operative interferences, and a critical study of the relationship between the pigment output and red cell count in parenteral anemias. It would seem that a study of the blood-derived pigments before and after splenectomy as undertaken above might shed some light on the reasonableness of the hypothesis of hypersplenism ; whereas the latter analyses would serve to demonstrate indirectly the state of the bone marrow. Incidentally a variety of nonhemolytic diseases have been studied, including enteral-bleeding anemias with pernicious-like blood pictures. Following precisely the technic elaborated in our previous work' we made a total of fifty-seven determinations in forty individual patients, which are here recorded. Of these, twenty-one are cases of

pernicious anemia and one


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