In spite of a number of observations on the balance of nitrogen, phosphorus, calcium and other elements in the metabolism of cretins, there appears to be only one series of experiments on record in which careful determinations of the amounts of the various nitrogenous constituents of the urine were made. These were reported by Scholz1 in 1906. According to him, the nitrogen partition is practically normal. Unfortunately, of the methods then available, only those for the deter
mination of nitrogen, urea and ammonia can be considered at all reliable. More recently, McCrudden9 studied the excretion of creatinin and creatin in a cretin. The amount of creatin eliminated was much less than in other types of arrested development and was greater on a carbohydrate-rich diet than on one rich in fat. The sulphur metabolism of cretins has, apparently, never been studied.