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ATTEMPTS TO PRODUCE SCARLATINA IN MONKEYS

CHARLES KRUMWIEDE Jr.; MATTHIAS NICOLL Jr.; JOSEPHINE S. PRATT
Arch Intern Med (Chic). 1914;XIII(6):909-912. doi:10.1001/archinte.1914.00070120071006.
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Notwithstanding the numerous attempts to inoculate the lower monkeys with scarlet fever, the positive results reported, notably those of Cantacuzène1 and Bernhardt,2 have not been substantiated by others who have repeated the experiments of these observers. (Notes 1 to 4 give the complete recent literature.) Thus Landsteiner and Levaditi3 inoculated thirty-five monkeys of five different lower species with exudate from the throat and with the blood and lymph-nodes of scarlet-fever patients, by local application to the fauces of the animals and by intravenous, intraperitoneal and subcutaneous injections of scarlet-fever products without obtaining a seemingly positive result. Klimenko,4 making use of twenty monkeys of five lower species, was equally unsuccessful, although he included among his many experimental procedures that of Bernhardt, who claims to have produced the disease in fourteen out of nineteen aimals. Shortly after the publication of Cantacuzène's first papers, Dr. Park inoculated six

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