The discovery by Blum1 that administration of epinephrin caused glycosuria at once suggested that its action might be due to an effect on the pancreas. This hypothesis was tested by Herter and Wakeman,2 who found that direct application of epinephrin solutions to the pancreas caused the appearance of sugar in the urine. Benedicenti3 and Pemberton and Sweet4 showed that epinephrin injections diminish the flow of pancreatic juice. The last-named authors suggested the possibility that the "internal secretion" of the pancreas was likewise inhibited and therefore diabetes resulted. Edmunds,5 however, set forth that the inhibition of the pancreatic flow was due to a reduced blood-supply to the gland brought about by vasoconstriction.
An elaborate theory as to the action of epinephrin was promulgated by Falta, Eppinger and Rüdinger,6 a theory which has had the support of von Noorden,7 whose pupils