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ARTICLE | August 1913

CULTURAL RESULTS IN HODGKIN'S DISEASE

C. H. BUNTING, M.D.; J. L. YATES, M.D.

Arch Intern Med (Chic). 1913;XII(2):236-242. doi:10.1001/archinte.1913.00070020122012.

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The publication at this time of the result of our endeavors to cultivate an organism from the tissues of patients with Hodgkin's disease is occasioned by the publication by Negri and Mieremet¹ of the successful cultivation from two cases of Hodgkin's disease of a diphtheroid organism which they designate as the Corynebacterium granulomatis maligni.

While Hodgkin's disease, or malignant granuloma of the lymphatic apparatus, has of late years come to be generally regarded as of infectious nature, the etiological agent has remained undetermined. The work in this country of Reed² and of Longcope³ showed definitely that the condition was independent of tuberculosis, and that the theory supported by Sternberg⁴ that it was a manifestation of the activity of the tubercle bacillus could not be maintained.

In 1900 Fraenkel and Much⁵ reported that by treating Hodgkin's nodes with a strong alkalin solution of sodium hypochlorid

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BUNTING CH, YATES JL. CULTURAL RESULTS IN HODGKIN'S DISEASE. Arch Intern Med (Chic). 1913;XII(2):236-242. doi:10.1001/archinte.1913.00070020122012.

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