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STUDY XX: THE EFFECT OF DIURETIC DRUGS ON THE LIFE OF ANIMALS WITH SEVERE ACUTE NEPHRITIS

CHANDLER WALKER, M.D.; R. P. DAWSON, M.D.
Arch Intern Med (Chic). 1913;XII(2):171-177. doi:10.1001/archinte.1913.00070020057005.
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In a previous paper, Christian and O'Hare1 have reported a detrimental effect of the diuretic drug, diuretin, in severe acute nephritis produced in rabbits by injections of uranium nitrate. Therefore, we were interested to study the effects of other drugs commonly employed by clinicians as diuretics, such as theocin, caffein, potassium acetate and spartein sulphate. The latter drug is included, as it is used by some clinicians as a diuretic, though not generally regarded as a diuretic in the same sense as the others.

Acute nephritis was produced in rabbits by uranium nitrate. Three and one-half mg. of uranium nitrate was dissolved in 1 c.c. of sterile distilled water, and the solution so made was given intravenously. Each animal received two doses twenty-four hours apart of 3.5 mg. of uranium nitrate per kilo of body weight. Uranium nitrate was employed to produce the nephritis because it causes a

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