The circulating fluids of the organism are practically neutral and nearly constant in reaction, and an animal, into whose body acid is being introduced, dies before his serum gives an appreciably acid reaction. Nevertheless, the trend of metabolism is toward the production of acid greatly in excess of alkali; but under normal conditions the whole of this excess is separated from the blood in its passage through the kidney. One of us has shown the chemical mechanism which underlies
Chart 1. Chart 2.
Chart 1.—Case 1.
Double hydrothorax; large ascites; marked general anasarca; arteriosclerosis; cardio-renal. Blood-pressure 160. Made a rapid and uneventful recovery.
Chart 2.—Case 2.
Mitral disease. No hydrothorax, ascites or edema. Moist râles in lungs. Improved rapidly.The solid line in this and other charts represents the twenty-four hour amount of urine in cubic centimeters. The broken line represents the hydrogen ion concentration in each twenty-four-hour