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STUDY XVIII: ACUTE RENAL LESIONS PRODUCED BY URANIUM NITRATE IN THE DOG IN COMPARISON WITH THE RABBIT

JAMES P. O'HARE, M.D.
Arch Intern Med (Chic). 1913;XII(1):61-63. doi:10.1001/archinte.1913.00070010064005.
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In 1908, Christian1 described the occurrence of hyaline droplets in the walls of the capillaries of the glomerular tuft in rabbits that had recently received doses of uranium nitrate. In 1911, a further study of this lesion was published.2 At Dr. Christian's suggestion, I undertook to see whether a similar lesion could be produced in dogs by injection of uranium nitrate.

Nine dogs of varying breeds and weights were tested by urinary examination to exclude a possible spontaneous nephritis. They then were given subcutaneous injections of uranium nitrate. The number of doses and their time interval differed considerably, varying from a single dose of 3.3 mg. per kilo of body weight to three doses of 12 mg. per kilo of body weight. Except in two instances, the doses were given on successive days, and the animal killed twenty-four hours after the last dose by primary chloroform anesthesia

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