Of great importance in relation to the surgery of the kidney is the is the question concerning the length of time that the renal vessels may be clamped without permanent injury to renal function or renal tissue. The question is dealt with here experimentally. The renal vessels in rabbits and dogs have been clamped for varying periods of time, and subsequently renal function has been tested by the excretion of phenolsulphonephthalein, lactose, potassium iodid, salt and water. The presence or absence of albumin and casts in the urine has been observed. The results of such functional studies have been controlled by histological examination of the kidneys.
The effect of obstruction to the renal circulation on the urinary picture and the histology of the kidney has already been investigated. Robinson1 showed that tying of the renal vein resulted in the appearance of albumin, blood, or both, in the