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THE HISTOPATHOLOGY OF THE NERVOUS SYSTEM IN PELLAGRA

H. DOUGLAS SINGER, M.D., M.R.C.P.; LEWIS J. POLLOCK, M.D.
Arch Intern Med (Chic). 1913;XI(6):565-589. doi:10.1001/archinte.1913.00060300002001.
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The study of the nervous system in pellagra has been made, to a very large extent, only with the older methods of staining, and it is our purpose here to present the findings in a series of cases in which the more modern methods have been used.

The actual number of papers on the pathologic anatomy of the nervous system in pellagra is not very great and the conclusions reached are somewhat variable. By some the changes are regarded as characteristic and peculiar, whereas others see in the various findings only the expression of a generalized intoxication not in any way specific for this disease. The question is of some importance in relation to the widespread belief in the occurrence clinically, of a certain nervous and mental symptom-picture which is supposedly necessary for the diagnosis of pellagra. Another controversial feature, which stands out prominently, is the

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