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EXPERIMENTAL NOTES ON THE INFLUENCE OF THE ADRENALS OVER THE PANCREAS

RALPH PEMBERTON, M.D.; J. E. SWEET, M.D.
Arch Intern Med (Chic). 1912;X(3):169-176. doi:10.1001/archinte.1912.00060210003001.
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In a series of previous contributions, we have dealt at some length with certain relations between the pancreas and other organs of the body, particularly the ductless glands. Our experimental work covered a period of about five years, and it may be well, better to understand our present remarks, to repeat the main conclusions reached. For our present purposes they are as follows:

  1. The flow of juice from the pancreas, whether excited by secretin injected intravenously, by HCl placed in the duodenum, or by normal chyme, may be inhibited by the intravenous injection of extracts of the pituitary or adrenal glands.

  2. This inhibition may last some time after the body as a whole seems to have recovered from the rise in blood-pressure and is independent of systemic blood-pressure. The exact modus operandi is not clear.

  1. Removal of the adrenal glands from otherwise normal dogs under circumstances which allow of observation of the flow of pancreatic juice, induces sooner or later a flow from the pancreas which persists until death, and sometimes lasts for hours

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