Arch Intern Med (Chic). 1911;VII(5):694-719. doi:10.1001/archinte.1911.00060050116009.
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HISTORICAL REVIEW  Attention was called to the possible value in nutrition of oils and fats given subcutaneously, by von Leube1 in 1895. He remarked the rapid disappearance of very large injections of camphorated oil which he was giving for stimulation and sought to find whether oils remained in the tissue spaces or were utilized in nutrition.An emaciated dog, previously brought into nitrogenous equilibrium at a very low level, was given daily subcutaneous injections of butter-fat for over six weeks in an amount which equaled about 1,400 gm. The weight rose from 4.4 kilos to 5.4 kilos. A laparotomy performed at the end of the injection period showed large masses of extraperitoneal fat, two-thirds of which was butter-fat. The omental fat consisted wholly of dog-fat. On a very low ration of fat-free meat at the end of a further three and one-half months, the same dog weighed 4.1 kilos,


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