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THE PROBLEMS OF EXPERIMENTAL NEPHRITIS

RICHARD M. PEARCE, M.D.
Arch Intern Med (Chic). 1910;V(2):133-167. doi:10.1001/archinte.1910.00050240042005.
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Our present knowledge of nephritis is the result of the methods of clinical observation, pathological anatomy and experimental pathology, successively applied. By means of the first of these, Richard Bright, in 1827, demonstrated that albuminuria and dropsy had an intimate relation to certain pathological changes in the kidney. Studies in pathological anatomy during the following years led to the differentiation of several types of nephritis, and, finally, to a classification based on morphological alterations. I do not think it an exaggeration to say that clinical observation has added little of essential importance to Bright's original conception of eighty years ago, or that pathological anatomy has added little to Weigert's classification, which has been generally accepted for thirty years. Bright's views, it is true, have been amplified, certain phases of the relation of renal disease to cardiovascular disturbances have been more clearly understood, and much negative evidence concerning

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