For a number of years observations have been carried on, in connection with the clinic of Dr. Frank Billings, at Rush Medical College, with reference especially to chronic focal infections and associated systemic disease. The more general features and the therapeutic results of this work are presented in the preceding article by Dr. Billings. Here will be given chiefly some bacteriologic and experimental data derived largely from a study of cases which came under his observation.
Some of the first work undertaken had to do with genito-urinary disease and chiefly with infections of the urinary bladder by bacteria of the colon group. From the study of many organisms of this variety it has been found that they vary, to a certain extent, both in morphology and in cultural reactions. Some are short and plump; others slender and long. All are Gram-negative. Some grow profusely on ordinary media, others give