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Arch Intern Med (Chic). 1912;IX(1):32-43. doi:10.1001/archinte.1912.00060130037003.
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Since the appearance of Fröhlich's paper1 in 1901, it has become generally recognized that tumors in or near the pituitary gland may cause disturbances of body growth and general metabolism which are quite distinct from acromegaly and gigantism. Frankl-Hochwart2 has recently collected and analyzed the findings in 155 pituitary affections of this character. The symptoms present may be roughly divided into two classes : those due to the mechanical effects of the tumor and those which seem to be due to an altered internal secretion. To the former group belong the headache, vomiting and visual disturbances. The most characteristic of these, primary optic atrophy and unilateral or bilateral temporal hemianopsia, are due to direct pressure on the optic chiasm or nerves. To the latter group belong the sexual disturbances (retarded sexual development, cessation of menses, etc.), the obesity, the stunted growth, and possibly the occasional diabetes


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