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December 1909, Vol IV, No. 6 >
ARTICLE | December 1909

THE RELATION OF HYPERSUSCEPTIBILITY TO IMMUNITY

PAUL A. LEWIS, M.D.
Arch Intern Med (Chic). 1909;IV(6):528-537. doi:10.1001/archinte.1909.00050220014002.
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The circumstance that the repeated treatment of animals with certain substances, by appropriate methods, tends to establish a state of specifically decreased tolerance for those substances has attracted much attention within the last two or three years. The problems which arise when it is attempted to account for this phenomenon or to make practical use of its specific character have been attacked in most of the laboratories concerned in research in the field of immunity, and in at least two purely physiological laboratories. Not the least interesting and important of these problems concerns the relation which may or may not exist between this phenomenon of specifically decreased resistance and the increased resistance or immunity which is so often obtained when toxins, bacterial products or living bacteria are repeatedly given to an animal in suitable fashion. The contrast between the two conditions is selfevident, and while, as our knowledge

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