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THE PRODUCTION OF MORBID CHANGES IN THE BLOOD VESSELS OF THE RABBIT BY ALCOHOL:  A PRELIMINARY REPORT

WILLIAM DE B. MAC NIDER, M.D.
Arch Intern Med (Chic). 1909;III(2):175-179. doi:10.1001/archinte.1909.00050130086006.
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INTRODUCTION  The production of morbid changes in the lower animals by the use of drugs, various chemicals and, in some cases, by the employment of mechanical devices has opened an instructive field for medical investigation. The general aim of such investigation has been, first, to determine whether definite and fairly constant pathologic changes could be produced by the use of various agents, and, second, after this has been determined, to arrest or to modify these changes by the use of other agents of a remedial nature.In recent years there has been developed an extensive literature through the work of various investigators on experimental arteriosclerosis. The contributions of Josué, Fischer, Kurt, Klotz, Miller1 and others have demonstrated that degenerative arterial changes follow the intravenous injection of adrenalin, digitalin and diphtheria toxin. Boinet and Romany and Klotz, using the Bacillus typhosus and streptococcus, have with the same

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