Evidence of regeneration of the blood is of great value not only in the diagnosis, but also in the prognosis and treatment of anemias. Among the most important regenerative signs may be mentioned the occurrence of nucleated red blood cells, of basophilic granules in the erythrocytes, and of polychromatophilia. Recently I have described another manifestation of regeneration found in the human red corpuscles in anemias and in embryonic blood, and subsequent work has served to confirm the views previously expressed, with one or two exceptions.
The small, round or oval, eccentrically placed bodies, first described by Howell and later by Schmauch, in the erythrocytes of the cat, are best seen when stains are added to the fresh blood. These have been considered identical with bodies answering to the same general description morphologically found in permanent stained preparations of blood by subsequent observers—Pol, Schmidt, Jolly and myself. There are, however, differences,