Arch Intern Med (Chic). 1908;II(5):448-503. doi:10.1001/archinte.1908.00050100057002.
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(Concluded from page 354.) II. PHYSIOLOGIC CHEMISTRY OF ACETONE COMPOUNDS.  The significance of acidosis must eventually be determined by the chemistry and physiology of the substances in question. The enormous quantities of acetone compounds found in diabetes are of much interest, but they may be of no more importance for the symptoms of the disease and no closer index of its nature than is the enormous excretion of sugar. We believe that sugar is neither directly nor indirectly a toxic agent in diabetes, but the doctrine of acid intoxication supposes that the acetone compounds are directly responsible for some of the most striking symptoms. Indeed, if this doctrine is accepted in its entirety most of the serious symptoms of the disease must be connected with these substances. As the direct study of diabetes has not succeeded in fully establishing the position of acid intoxication, new light must be sought


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