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ARTICLE |

THE THEORY OF CHEMICAL CORRELATION AS APPLIED TO THE PATHOLOGY OF THE KIDNEY.

RICHARD M. PEARCE, M.D.
Arch Intern Med (Chic). 1908;II(1):77-106. doi:10.1001/archinte.1908.00050060084006.
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There is perhaps no problem in medicine of greater interest to clinician and pathologist alike than that of the relation which some of the more important manifestations of chronic nephritis, as vascular hypertension, heart hypertrophy, uremia and edema, bear to the renal lesion itself. During the past summer, having in view an experimental study of some phases of vascular hypertension, I undertook a critical review of the general literature of renal physiology and pathology, and was amazed, not only at the multiplicity of theories concerning the relation of the kidney to heart hypertrophy and hypertension, but also at the importance attached by many writers to the part played by the hypothetical internal secretion of the kidney. I use the term "hypothetical" advisedly, for, although certain clinical observations are very suggestive, the experimental basis on which the theory rests appeared to me to be most unstable. Further study of

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