The pathophysiologic explanations
of disease—the machinations behind
manifestations—have always attracted serious students of medicine.
Each year origins are traced a step
closer to ultimate sources as old tools
are refined and new ones devised to
permit deeper and deeper penetration to the core of the matter.
Many fine books have been written
in an effort to correlate mechanisms
and manifestation, but none is superior to this magnificent offering
by Talso and Remenchik. With the
help of 31 contributors, they have
compiled a comprehensive, authoritative text that embodies the virtues
of crisp semantics, remarkable timeliness (for a textbook), and commendable brevity.
It is designed primarily for medical students, and its occasional
overtones of dogmatism are appropriate. Quite impressive are the
summary charts and multitudes of
original diagrams and drawings
(with clear legends) that implement
understanding of physiologic and
pathogenetic pathways. I particularly enjoyed the chapters on basic
mechanisms, cardiovascular diseases,