The case is reported of a 39-year-old pregnant woman who
presented with fever, abdominal complaints, and diarrhea. Laboratory investigation revealed mononucleosis in the peripheral
blood. All microbiological studies were negative, with the exception of finding cytomegalovirus (CMV). Seroconversion was documented; the virus was cultured from urine and subsequently
was demonstrated to be present in the inflamed mucosa of the
rectum and distal sigmoid, which was found at sigmoidoscopy.
This woman was delivered of a neonate with congenital CMV
infection but without apparent malformations. The patient experienced recurrences of the bowel disease, in the first of which
CMV could still be cultured from a biopsy specimen. In the follow-up period, an otherwise aspecific chronic inflammatory bowel
disease remained present. No immunological abnormalities
were found, and antibodies to human immunodeficiency virus
were negative. This case demonstrates that inflammatory bowel
disease can develop as a result of primary infection with CMV.
(Arch Intern Med. 1990;150:1749-1751)