High-density lipoprotein comprises two main types of lipoprotein particles: (1) those that contain apolipoproteins A-I and
A-II, designated LpA-I:A-II, and (2) those that contain apolipoprotein A-I but not apolipoprotein A-II, designated LpA-I. Both have
been extensively studied and are believed to represent distinct
metabolic entities that may confer differing protection against
coronary artery disease risk. We have previously suggested that
LpA-I might represent the antiatherogenic effect, which has been
ascribed mainly to its effect on high-density lipoprotein cholesterol; we set out to investigate, in 344 men, the relation between
LpA-I:A-II and LpA-I levels and alcohol consumption. As the
alcohol intake rose, LpA-I:A-IIII levels increased, while LpA-I levels fell. On the assumption that LpA-I is the antiatherogenic
fraction of high-density lipoprotein, the putative protective action of alcohol consumption against coronary artery disease
should be reconsidered.
(Arch Intern Med. 1990;150:1638-1641)
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