Enormous advances have been made in our understanding of the role of apolipoproteins in the
transport of plasma lipids. The apolipoproteins are
essential for the packaging of lipoproteins in the liver
and intestine, for the interconversion of lipoproteins
in the circulation, and for their uptake by tissues. In
a sense, the apolipoproteins are the "business end"
of the lipoproteins. Since the serum lipoproteins
undoubtedly play an important role in atherogenesis,
it is reasonable to ask whether serum levels of
apolipoproteins can be used as predictors of coronary
heart disease (CHD) in the same way that serum
cholesterol levels are used for this purpose. The two
apolipoproteins that have received the most attention
are apolipoprotein B and apolipoprotein A-I. Consideration might be given to the potential value of
measurement of each.