Periodic or cyclic neutropenia is considered
to be a rare hematological disorder,
characterized by a chronic rhythmic recurrence
of severe neutropenia or agranulocytosis
at approximately three-week intervals.
Ordinarily the worst phase of the neutropenia
extends for five to eight days, and this
may be associated with a compensatory rise
in the monocytes or eosinophils, particularly
if there is a normal number of leukocytes
present.1 During this same period serial
bone marrow studies have been reported by
some observers to show a complete suppression
of the granulocytic series, from
the myeloblast to the mature neutrophil1-5;
others have noted only a maturation arrest
at the promyelocyte level, a result probably
due to the lack of serial aspirations.6-9 During
the normal or relatively normal intervals
between the episodes of severe neutropenia,
the bone marrow is normal. On two
occasions there have been abnormal concentrations
of platelets associated with this
disease; one author10 reported
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