By 1956 the total number of reported
cases of cryptococcosis was over 300,1-5 and
the total has been added to since. It seems
reasonable to assume that there may be
many other unreported cases, or cases in
which Cryptococcus is the likeliest etiology
but could not be proved.
The commonest type of infection is of
the central nervous system, but cases have
been reported of primary cryptococcosis in
the skin2 and one case of visceral cryptococcosis
that presented a clinical picture of
granulocytic leukemia3 before death. There
are four reports of Cryptococcus infection
of the eye, all made postmortem.4-8 Cryptococcosis
has also been found to be responsible
for cases of adrenal insufficiency,
coexistent with Hodgkin's disease, tuberculosis,
and histoplasmosis, in which cases the
clinical findings were of a rather bizarre
nature. The clinically confused picture
often found has led to the declaration that
"perhaps it can be postulated that any
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