Second Field Evaluation of Bivalent Types 4 and 7 Adenovirus Vaccine

Maurice R. Hilleman; Capt. Jerome H. Greenberg; Mildred S. Warfield; Sally A. Anderson; Richard R. Glabere
AMA Arch Intern Med. 1958;102(3):428-436. doi:10.1001/archinte.1958.00030010428013.
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Earlier reports1-5 from this laboratory described the development and evaluation in the field of a formalin-killed bivalent adenovirus6-8 vaccine of monkey-kidney origin. The vaccine was prepared at the Walter Reed Army Institute of Research, and the evaluation consisted of a controlled field study conducted during the winter of 1956 in 624 newly inducted recruits at Fort Dix, N. J. The vaccine was highly effective, commencing one week after vaccination, and produced a 98% reduction in amount of adenovirus-caused respiratory illness. During the winter of 1957, a second controlled field evaluation of the vaccine was carried out among 8238 recruits stationed at Fort Leonard Wood, Mo. The vaccine employed in this trial was provided by Lederle Laboratories and was prepared under commercial conditions. This paper presents the findings in the field trial at Fort Leonard Wood, compares the potency values of the Lederle and Walter Reed vaccines, and presents data concerning


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