Earlier reports1-5 from this laboratory
described the development and evaluation
in the field of a formalin-killed bivalent
adenovirus6-8 vaccine of monkey-kidney
origin. The vaccine was prepared at the
Walter Reed Army Institute of Research,
and the evaluation consisted of a controlled
field study conducted during the winter of
1956 in 624 newly inducted recruits at Fort
Dix, N. J. The vaccine was highly effective,
commencing one week after vaccination, and
produced a 98% reduction in amount of
adenovirus-caused respiratory illness. During
the winter of 1957, a second controlled
field evaluation of the vaccine was carried
out among 8238 recruits stationed at Fort
Leonard Wood, Mo. The vaccine employed
in this trial was provided by Lederle Laboratories
and was prepared under commercial conditions. This paper presents the
findings in the field trial at Fort Leonard
Wood, compares the potency values of the
Lederle and Walter Reed vaccines, and
presents data concerning
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