For the student of neuromuscular disorders,
the thyroid gland poses several unsolved
problems. Thus, hyperthyroidism has
been shown to be associated with myopathy
and ophthalmoplegia and may be related in
some manner to myasthenia gravis and periodic
paralysis.1 Similarly, the concurrence
of hypothyroidism and muscle dysfunction
has been noted repeatedly.2 Again, certain
questions have arisen concerning the part
played by thyroid hypofunction in myotonia.
Five principal types of association are at
A majority of patients with evident
myxedema will show a delay in the relaxation
of muscle after deep tendon reflexes
are elicited. The phenomenon has been
termed pseudomyotonia. Lambert3 demonstrated
that the delay includes all phases of
the tendon reflex, but only the slowing of
relaxation is obvious clinically. Hormone
replacement sufficient to correct the basal
metabolic rate and the clinical signs of
myxedema eradicates the pseudomyotonia.
While the nature of the disturbance in muscle function is not
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