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Platelet Gigantism Associated With Cholestyramine Therapy

Véronique Latger-Cannard, MD; Danièle Sommelet, MD, MPH; Bruno Guerci, MD; Philippe Tréchot, MD; Thomas Lecompte, MD, PhD
Arch Intern Med. 2001;161(21):2619-2620. doi:.
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Although cholestyramine has been widely prescribed for many years in the treatment of hypercholesterolemia, to our knowledge there have been no reports of platelet disorder induced by this drug. We report a case of platelet gigantism in a child receiving treatment with cholestyramine.

McDonald  GBVracko  R Systemic absorption of oral cholestyramine. Gastroenterology. 1984;87213- 215
Stöckler  SMolzer  BPlecko  B  et al.  Giant platelets in erucic acid therapy for adrenoleukodystrophy. Lancet. 1993;3411414- 1415
Link to Article[[XSLOpenURL/10.1016/0140-6736(93)90984-O]]
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Platelet count analysis with a hematological analyzer (Coulter STKS; Beckman Coulter Inc, Fullerton, Calif) showing an abnormal volume distribution with number of platelets in arbitrary units (A). Large (B) and giant (C) platelets on a May-Grünwald-Giemsa–stained blood smear (original magnification ×100).

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