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DRESS Syndrome Associated With Nevirapine Therapy

Gloria Alonso Claudio, MD; Aurelio Fuertes Martin, MD; Sofía de Dios Perrino, MD; Agustín Arévalo Velasco, MD
Arch Intern Med. 2001;161(20):2501-2502. doi:.
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Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome or hypersensitive syndrome has been associated with the use of aromatic anticonvulsants, sulfonamides, calcium channel blockers, allopurinol, ranitidine, and thalidomide. The clinical manifestations include a diffuse maculopapular rash, fever, multivisceral involvement, eosinophilia, atypical lymphocytosis, and abnormal liver function test results.1

Nevirapine is a potent and selective noncompetitive inhibitor of the reverse transcriptase enzyme of human immunodeficiency virus (HIV) type 1, inhibiting reverse transcriptase by binding to tyrosine components of the enzyme, which are located near the catalytic site.2 It was the first nonnucleoside reverse transcriptase inhibitor approved for clinical use in patients infected with HIV and is used in combination with other antiretroviral agents.3,4

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